Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy

Neurostimulation for epilepsy, including a pilot study of anterior nucleus stimulation.

Epilepsy is a common disorder, affecting approximately 0.7% of the population of the United States and of the world. The mainstay of therapy is medication, but only approximately two-thirds of individuals with epilepsy come under satisfactory control with medications (22). Some whose epilepsy cannot be medically controlled can be cured or substantially improved by resective surgery. However, th...

7.01.143 Responsive Neurostimulation for the Treatment of Refractory Partial Epilepsy

[TOP] Responsive neurostimulation (RNS) may be considered medically necessary for patients with partial epilepsy who meet ALL of the following criteria:  Are 18 years or older.  Have a diagnosis of partial-onset seizures with 1 or 2 well-localized seizure foci identified.  Have an average of 3 or more disabling seizures (e.g., motor partial seizures, complex partial seizures, or secondary ge...

Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy

Cognitive improvement after long-term electrical stimulation of bilateral anterior thalamic nucleus in refractory epilepsy patients

INTRODUCTION The cognitive and behavioral effect of deep brain stimulation (DBS) administered to the deep cerebral nuclei for epilepsy treatment is unknown. We investigated the cognitive outcomes at least 12 months after DBS to the bilateral anterior thalamic nucleus (ATN) for controlling intractable epilepsy. METHODS Nine patients with intractable epilepsy who were not candidates for resecti...

Epilepsy, Consciousness and Neurostimulation

Consciousness is often disrupted in epilepsy. This may involve altered responsiveness or changes in awareness of self and subjective experiences. Subcortical arousal systems and paralimbic fronto-parietal association cortices are thought to underpin current concepts of consciousness. The Network Inhibition Hypothesis proposes a common neuroanatomical substrate for impaired consciousness during ...